What is the Origin of Reverse T3 Correction?

This specialized clinical term arises from advanced thyroidology, particularly in the treatment of Non-Thyroidal Illness Syndrome (NTIS) or Euthyroid Sick Syndrome. It moves beyond standard TSH and T4 testing to address the critical peripheral metabolism of thyroid hormones. This approach recognizes that laboratory "normal" does not always equate to functional "optimal."

What is the Mechanism of Reverse T3 Correction?

Elevated rT3 is often a protective mechanism triggered by chronic stress, inflammation, or caloric restriction, where the body shunts T4 conversion away from active T3 toward inactive rT3 to conserve energy. Correction involves addressing the underlying metabolic stressors, providing specific micronutrients that support the Type 1 deiodinase enzyme, which converts T4 to T3. In some cases, targeted T3 replacement therapy may be used to outcompete rT3 at the receptor site.

Reverse T3 Correction ∞ Area

Reverse T3 Correction

Meaning

Reverse T3 Correction is a specific clinical strategy aimed at reducing elevated levels of reverse triiodothyronine (rT3) to restore the optimal ratio of free triiodothyronine (fT3) to rT3. Reverse T3 is an inactive thyroid metabolite that can competitively block T3 receptors, effectively creating a state of tissue-level hypothyroidism despite normal circulating T4 levels. The correction is essential for resolving symptoms of low thyroid function and restoring metabolic efficiency.