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Return of Menses

Meaning

Return of Menses refers to the clinical event of the resumption of regular, cyclic menstrual bleeding in a female who has experienced a period of amenorrhea, or absence of menstruation, due to a reversible cause. This event signifies the successful re-establishment of the functional Hypothalamic-Pituitary-Ovarian (HPO) axis and the restoration of normal ovulatory cycles. It is a key clinical endpoint in treating conditions like functional hypothalamic amenorrhea, indicating a return to a state of reproductive competence and hormonal balance.