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Retrograde Signaling

Meaning

Retrograde Signaling is a non-traditional form of intercellular communication where a signaling molecule travels backward across the synapse or between cells, originating in the postsynaptic cell and acting on the presynaptic terminal or an adjacent cell. This process is crucial for regulating synaptic strength, plasticity, and the coordinated release of neurotransmitters, ensuring that the sending cell adjusts its output based on the receiving cell’s activity. In the neuroendocrine system, this is essential for feedback regulation.