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Retinoic Acid Receptors

Meaning

Retinoic Acid Receptors (RARs) are a class of nuclear receptors that function as ligand-activated transcription factors, primarily mediating the biological effects of retinoic acid, a crucial metabolite of Vitamin A. These receptors are essential regulators of gene expression involved in cellular differentiation, proliferation, apoptosis, and embryonic development across various tissues, including the skin, bone, and immune system. Clinically, their modulation is central to dermatological treatments aimed at anti-aging and acne management.