The accuracy and clarity of the light signal transmitted from the retina to the Suprachiasmatic Nucleus (SCN), the brain’s master clock, which is crucial for synchronizing the circadian rhythm. High fidelity implies a robust signal of bright light during the day and minimal, low-intensity light at night, providing the SCN with unambiguous temporal information. Low fidelity, often due to artificial light exposure after sunset, leads to circadian misalignment and hormonal dysregulation.
Origin
The term combines ‘retinal input,’ referring to the light signal received by the eye, with ‘fidelity,’ a term borrowed from signal processing meaning faithfulness to the original source. This concept emerged from chronobiology to describe the quality of the primary zeitgeber for the circadian system. It emphasizes that the biological impact of light is determined by its temporal pattern and spectral composition, not just its visual function.
Mechanism
The fidelity is determined by the contrast between strong melanopsin activation from blue-enriched light during the day and the near-total absence of this activation at night. The retinohypothalamic tract transmits this signal to the SCN, which then regulates downstream functions, including the pineal gland’s melatonin secretion. Compromised fidelity, such as exposure to bright light after sunset, inappropriately delays the SCN’s phase, impairing the timing of nocturnal repair processes.
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