What is the Origin of Resistance Training Myokines?

The term combines "resistance training," referring to the specific mode of exercise, with "myokines," a classification of muscle-derived cytokines first coined in the mid-2000s. The identification of these molecules is a key advancement in exercise endocrinology, establishing skeletal muscle as a major endocrine organ that actively communicates with the rest of the body.

What is the Mechanism of Resistance Training Myokines?

The mechanical strain and micro-trauma from resistance training stimulate the release of specific myokines, such as Interleukin-6 (IL-6) and various growth factors, in a pattern distinct from aerobic activity. These myokines then act in an autocrine (on the muscle itself), paracrine (on adjacent tissues), and endocrine (on distant organs) manner. For instance, some myokines directly promote satellite cell activation and differentiation, while others enhance insulin sensitivity in the liver and adipose tissue, orchestrating a systemic anabolic and anti-inflammatory response.

Resistance Training Myokines ∞ Area

Resistance Training Myokines

Meaning

Resistance Training Myokines are a distinct subset of signaling proteins, or cytokines, released by skeletal muscle fibers in response to the mechanical tension and metabolic stress induced by resistance exercise. Unlike myokines released during endurance exercise, these specific peptides mediate muscle hypertrophy, tissue repair, and bone density adaptations. They function as inter-organ messengers, influencing distant tissues like fat, liver, and bone to improve systemic metabolic health and anabolic signaling. Their presence signifies a powerful, positive adaptation to strength-based physical activity.