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Resilience Signaling Pathways

Meaning

Resilience Signaling Pathways are the interconnected molecular routes within cells that are activated by moderate, beneficial stress, a process known as hormesis, to initiate adaptive and protective responses, thereby enhancing the cell’s capacity to withstand subsequent, more severe stressors. These pathways are absolutely crucial for cellular maintenance, meticulous DNA repair, and the detoxification of damaged proteins, effectively acting as the body’s intrinsic defense system against the cumulative molecular damage associated with aging. Robust and easily activated resilience signaling is a biological prerequisite for successfully extending an individual’s healthspan.