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Resilience Signaling

Meaning

Resilience Signaling refers to the body’s intricate and adaptive communication pathways, primarily involving the neuroendocrine and immune systems, that govern the capacity to maintain or rapidly restore physiological and psychological homeostasis following exposure to acute or chronic stressors. This signaling network determines the efficiency of the Hypothalamic-Pituitary-Adrenal (HPA) axis response, the modulation of inflammatory cascades, and the overall cellular stress response mechanisms. Optimal resilience signaling is clinically evidenced by a robust ability to adapt to environmental demands with minimal systemic debt, preventing the shift toward High-Friction Low-Yield Physiology.