The molecular and endocrine environment that dictates an organism’s capacity to withstand, adapt to, and recover from acute or chronic physiological and psychological stressors. This chemistry defines the robustness of homeostatic regulation. Optimal resilience is a marker of deep physiological health.
Origin
Rooted in stress physiology and endocrinology, this concept views the ability to return to baseline after a challenge as a function of underlying biochemical stability. It recognizes that sustained stress depletes critical resources.
Mechanism
Resilience chemistry is supported by a balanced $text{HPA}$ axis response, characterized by appropriate cortisol secretion and timely negative feedback. Sufficient availability of precursor molecules for catecholamine synthesis is also vital for acute adaptation. Furthermore, robust cellular energy reserves allow tissues to rapidly recover from the metabolic demands imposed by stress exposure.
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