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Resilience against Senescence

Meaning

This refers to the physiological capacity of cells, tissues, and entire organ systems to resist and recover from the accumulation of age-related damage and the transition into a state of cellular senescence—a non-dividing state that secretes pro-inflammatory factors. High resilience against senescence is characterized by robust DNA repair mechanisms, efficient protein quality control, and the sustained ability to clear senescent cells from the body. It is a critical determinant of long-term healthspan and tissue integrity.