Resilience against Distress is the inherent or conditioned capacity of the neuroendocrine system to rapidly return to or maintain physiological equilibrium following exposure to acute or chronic stressors without developing maladaptive sequelae. This reflects a robust and flexible HPA axis response pattern, rather than a flat or overly exaggerated one. High resilience minimizes the long-term impact of life challenges on systemic health.
Origin
The term draws from psychology and stress physiology, where ‘resilience’ describes adaptive coping, applied here specifically to the measurable physiological systems involved in stress response regulation.
Mechanism
Physiologically, resilience is underpinned by efficient negative feedback mechanisms that rapidly terminate the stress response once the threat is mitigated. This involves timely cortisol clearance and appropriate receptor sensitivity to maintain tight control over the HPA axis output. Furthermore, adequate tissue health, supported by optimal nutrient status, allows the body to rapidly resolve the transient metabolic shifts induced by the stressor, preventing a sustained inflammatory state.
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