The integrated cellular and molecular processes responsible for identifying, correcting, and replacing damaged components, including DNA, proteins, and organelles, to maintain tissue fidelity and function. These mechanisms are central to combating biological aging and recovering from physiological stress. They are the body’s intrinsic maintenance crew.
Origin
This term originates from cell biology and gerontology, focusing on pathways like DNA repair, chaperone protein activity, and autophagy, which actively counteract entropy. In the context of wellness, it emphasizes supporting these systems to promote regenerative capacity. It is about preserving structural integrity.
Mechanism
Key mechanisms involve the activation of DNA repair enzymes in response to genotoxic stress, often regulated by factors like PARP. Furthermore, optimal hormonal milieu, particularly adequate growth hormone and IGF-1 signaling, upregulates protein synthesis and autophagy to clear aggregated or damaged proteins. Supporting these systems ensures cellular quality control remains high.
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