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Renal Clearance

Meaning

Renal Clearance is a physiological measurement that quantifies the volume of plasma from which a specific substance is completely removed by the kidneys per unit of time. It is a fundamental metric used in clinical practice and pharmacology to assess kidney function and to determine the appropriate dosing of medications, including hormones and peptides. A high clearance rate indicates efficient removal by the kidneys, while a low rate suggests impaired renal function or minimal excretion of the substance. This measurement is crucial for maintaining stable drug and metabolite concentrations in the body.