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Redox Signaling

Meaning

Redox signaling is the complex biological process involving the communication pathways mediated by reactive oxygen species (ROS) and reactive nitrogen species (RNS), which function as crucial secondary messengers in cellular regulation rather than merely as damaging byproducts. This signaling system is vital for maintaining cellular homeostasis, regulating gene expression, and coordinating responses to stress, immunity, and growth factors. A disruption in the balance between oxidative species and antioxidant capacity, known as oxidative stress, can significantly impair hormonal receptor function and overall cellular health.