This term signifies a paradigm shift in the clinical and cultural understanding of the aging process, moving away from the traditional view of inevitable decline and disease accumulation toward a model of continuous functional optimization and maintenance of vitality. It is a proactive, evidence-based approach focused on modulating the fundamental biological mechanisms of aging to extend the healthspan, not just the lifespan. Redefining aging involves leveraging advancements in endocrinology and regenerative medicine to maintain peak human performance.
Origin
The concept is a philosophical and practical cornerstone of the modern longevity movement and anti-aging medicine, spurred by breakthroughs in genetic and cellular research that demonstrate the plasticity of the aging process. It challenges the fatalistic view of chronological age by focusing on quantifiable biological age markers and the potential for rejuvenation through targeted intervention. The term advocates for a clinical focus on the root causes of age-related functional loss.
Mechanism
The core mechanism involves intervening in the biological hallmarks of aging, which include genomic instability, telomere attrition, epigenetic alterations, and loss of proteostasis. Clinical strategies focus on supporting cellular repair pathways, optimizing mitochondrial function, and maintaining youthful hormonal signaling, such as balancing growth hormone and sex steroid levels. By mitigating systemic damage and enhancing cellular resilience, the physiological trajectory of age-related decline can be significantly altered and decelerated.
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