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Reconstituted Peptide Stability

Meaning

Reconstituted Peptide Stability refers to the ability of a lyophilized (freeze-dried) therapeutic peptide to maintain its chemical integrity, tertiary structure, and biological activity after it has been mixed with a sterile solvent, typically bacteriostatic water, for injection. This stability is a critical pharmaceutical parameter, directly influencing the drug’s efficacy and safety profile over its usable lifespan following preparation. Loss of stability often results in peptide degradation, aggregation, or reduced receptor binding affinity, leading to sub-therapeutic dosing.