Question 1

What is the Meaning of Recombinant Human FSH?

Accepted Answer

Recombinant Human FSH (r-hFSH) is a pharmaceutical preparation of Follicle-Stimulating Hormone, a gonadotropin protein naturally produced by the pituitary gland, that is manufactured using recombinant DNA technology. This biotechnologically engineered hormone is structurally and functionally identical to the endogenous human hormone, serving to stimulate follicular development in the ovaries of women and spermatogenesis in the testes of men. Clinically, r-hFSH is a cornerstone therapy in assisted reproductive technology, providing a highly purified, consistent, and standardized product for controlled ovarian stimulation and treatment of hypogonadotropic hypogonadism.

Question 2

What is the Origin of Recombinant Human FSH?

Accepted Answer

The term combines "recombinant," signifying its production through genetic engineering by inserting the human FSH gene into host cells, with "Human FSH," the native hormone it mimics. The need for a pure, non-urinary derived source of FSH led to the development of this recombinant technology in the late 20th century. This advancement significantly improved the safety and efficacy of fertility treatments by eliminating the variability and potential contaminants associated with older extraction methods.

Question 3

What is the Mechanism of Recombinant Human FSH?

Accepted Answer

The mechanism of action involves r-hFSH binding to specific FSH receptors (FSHR) located on the surface of granulosa cells in the ovarian follicles and Sertoli cells in the seminiferous tubules of the testes. Receptor binding activates an intracellular signaling cascade, primarily via the adenylyl cyclase pathway, which increases cyclic AMP (cAMP) production. This signal transduction promotes the proliferation of granulosa and Sertoli cells, enhances the local synthesis of sex steroids, and drives the maturation process of gametes in both the female and male reproductive systems.

Recombinant Human FSH

Meaning

Origin

Mechanism

How Do Gonadotropins and SERMs Restore Sperm Production Post-TRT?

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