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HRTioOctober 1, 2025
Receptor Upstream Regulation
Meaning
The molecular control mechanisms that govern the quantity, sensitivity, and functional state of hormone receptors on the cell surface or within the cell nucleus, occurring prior to the actual binding of the hormone. This regulation includes processes like receptor gene expression, synthesis, membrane insertion, and post-translational modification, all of which dictate the cell’s ultimate responsiveness to an endocrine signal. It is a critical determinant of hormonal efficacy.
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