Skip to main content

Receptor Site Desensitization Avoidance

Meaning

Receptor Site Desensitization Avoidance is a clinical strategy focused on preventing the phenomenon where prolonged exposure to high concentrations of a ligand, such as an administered hormone, causes the target cell to internalize or reduce the number of its surface receptors. This down-regulation impairs subsequent cellular responsiveness, effectively creating functional resistance to the treatment. Avoiding this process is crucial for maintaining the long-term efficacy of any endocrine modulation therapy. We aim for sustainable signaling, not saturation.