What is the Origin of Receptor Signaling Pathways?

The concept of specific cellular signaling originated with the elucidation of hormone action in the mid-20th century, particularly the "second messenger" hypothesis. The term combines "receptor," derived from the Latin recipere (to receive), with "pathways," denoting the sequence of molecular steps. This is a core concept in molecular biology and pharmacology.

What is the Mechanism of Receptor Signaling Pathways?

The mechanism typically involves the receptor undergoing a conformational change upon ligand binding, which then activates a series of intracellular proteins, often kinases or G-proteins. This activation cascade, known as signal transduction, amplifies the initial signal and directs it to effector molecules, such as transcription factors in the nucleus or metabolic enzymes in the cytoplasm. The specificity of the pathway ensures that each hormone elicits the correct, targeted physiological effect in its responsive tissues.

Receptor Signaling Pathways ∞ Area

Receptor Signaling Pathways

Meaning

The intricate, sequential cascade of molecular events initiated when a hormone or other signaling molecule binds to its specific receptor protein on or within a target cell. These pathways transduce the external hormonal signal into a specific internal cellular response, such as altered gene expression, enzyme activation, or membrane permeability. Understanding these signaling pathways is fundamental in clinical endocrinology for developing targeted therapies that can modulate cellular function with precision.

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HRTioJuly 22, 2025

Receptor Signaling Pathways

Meaning

Origin

Mechanism

How Do Peptides Specifically Influence Pituitary Gland Function?

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