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Receptor Signaling Fidelity

Meaning

Receptor Signaling Fidelity refers to the accuracy and precision with which a target cell receives, transduces, and executes the specific biological command initiated by a hormone binding to its cognate receptor. High fidelity ensures that the hormone’s message is clearly received and translated into the intended cellular response without noise or interference. Loss of fidelity, often termed “signaling resistance” or “receptor desensitization,” is a core pathology in numerous endocrine disorders, such as Type 2 Diabetes (insulin resistance) and thyroid dysfunction. Maintaining this precision is essential for effective hormonal health.