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Receptor Sensitization Dynamics

Meaning

Receptor sensitization dynamics describe the biological processes by which cellular receptors, particularly those for steroid hormones or neuropeptides, become more responsive to their corresponding ligands, effectively amplifying the downstream cellular signal. This heightened sensitivity can occur following a period of low or absent ligand exposure, or through specific pharmacological interventions. Understanding these dynamics is key to optimizing pulsed or cyclical hormone therapies to maximize therapeutic effect while minimizing desensitization.