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Receptor Sensitivity Tuning

Meaning

Receptor Sensitivity Tuning refers to the dynamic physiological process by which target cells modulate the responsiveness of their hormone receptors to circulating ligands, either upregulating or downregulating their activity. This fine-tuning is crucial for maintaining hormonal set points against fluctuating systemic concentrations, preventing over- or under-stimulation. It represents cellular adaptation within the endocrine feedback loop.