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Receptor Sensitivity Enhancement

Meaning

Receptor Sensitivity Enhancement is a therapeutic strategy focused on increasing the responsiveness of target cells to their corresponding signaling molecules, particularly hormones, by upregulating receptor expression or improving post-receptor signal transduction efficiency. This clinical approach is employed when circulating hormone levels are adequate but the biological effect is diminished due to cellular resistance, a common challenge in metabolic and endocrine aging. The goal is to maximize the efficacy of endogenous hormones without necessarily increasing their concentration.