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Receptor Saturation

Meaning

Receptor Saturation is a pharmacological and physiological state in which nearly all available receptor sites on a cell membrane or within the cytoplasm are occupied by their specific ligand, such as a hormone or neurotransmitter. Clinically, this concept is crucial in hormone replacement therapy, as it dictates the maximum possible biological effect achievable from increasing a hormone’s concentration. Once saturation is reached, further increases in the ligand concentration yield no additional clinical benefit.