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Receptor Level Signaling

Meaning

Receptor Level Signaling refers to the initial and critical step in the cellular communication process where a circulating hormone, neurotransmitter, or growth factor binds to its specific receptor protein on or within a target cell, thereby initiating a cascade of intracellular events. The number, sensitivity, and availability of these receptors are the primary determinants of a cell’s response magnitude, irrespective of the circulating hormone concentration. Clinical interventions often focus on modulating receptor expression or sensitivity to enhance therapeutic outcomes. Understanding this level is essential for overcoming cellular resistance.