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Receptor Gene Expression Control

Meaning

Receptor Gene Expression Control is the fundamental biological regulation of the transcription and translation processes that ultimately determine the precise quantity and functional characteristics of hormone receptors present on or within target cells. This complex control mechanism is a critical determinant of tissue sensitivity, as the magnitude of the cellular response to a circulating hormone is directly proportional to the number of available, functional receptors. Alterations in this gene expression can lead to clinical states of functional hormone resistance or, conversely, profound hypersensitivity.