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Receptor Expression Cycling

Meaning

The dynamic, regulated process by which the number of specific hormone receptors displayed on the surface or within a target cell is increased (upregulation) or decreased (downregulation) in response to changes in ligand concentration or other cellular signals. This cycling is a fundamental homeostatic mechanism that allows cells to maintain sensitivity to fluctuating hormonal signals and prevent overstimulation or desensitization. Clinically, understanding this cycling is crucial for optimizing dosing frequency in hormonal and peptide therapies.