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Receptor Expression

Meaning

Receptor Expression is the cellular process by which a cell synthesizes and displays functional protein receptors, typically on its surface or within its cytoplasm, that are capable of binding to specific signaling molecules like hormones or neurotransmitters. The density and functional status of these receptors are crucial determinants of a tissue’s sensitivity and responsiveness to hormonal signals, playing a pivotal role in endocrine efficacy. Alterations in receptor expression, such as downregulation due to chronic overstimulation or upregulation due to deficiency, are key mechanisms of hormonal resistance and sensitivity. Optimizing receptor expression is a target for enhancing therapeutic outcomes.