Receptor Downregulation Reversal

Meaning

Receptor Downregulation Reversal refers to the clinical strategy of restoring the optimal number and sensitivity of specific cellular receptors that have been diminished due to chronic overexposure to their corresponding ligand or pathological states. This reversal is critical because receptor downregulation leads to cellular resistance, wherein a high concentration of a hormone fails to elicit the proper biological response. Successfully achieving this reversal is a cornerstone of overcoming hormonal resistance and improving therapeutic efficacy. It is essential for restoring accurate cellular communication.

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