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Receptor Binding Interference

Meaning

Receptor Binding Interference is a pharmacological or physiological phenomenon where an exogenous substance, an endogenous antagonist, or even an autoantibody impedes the normal, high-affinity interaction between a hormone or peptide and its specific cellular receptor. This interference can occur via competitive antagonism, where the interfering agent occupies the binding site without activating the receptor, or via non-competitive means, where it binds to an allosteric site to alter receptor conformation. The clinical consequence is a blunted or absent endocrine signal, leading to a state of functional hormone resistance or impaired physiological regulation.