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Receptor Binding Fidelity

Meaning

Receptor binding fidelity refers to the clinical and molecular objective of ensuring the precise and exclusive binding of a hormone or signaling molecule to its intended, specific receptor without cross-reacting with other, non-target receptors. High fidelity minimizes off-target effects and guarantees that the physiological message is accurately transmitted, which is essential for maintaining the delicate balance of the endocrine system. Loss of fidelity can lead to aberrant signaling and downstream hormonal dysregulation.