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Receptor Affinity Variation

Meaning

Receptor Affinity Variation refers to the measurable differences in the binding strength and subsequent signaling efficacy between a hormone and its specific receptor protein across various tissues and individuals. This physiological variability can be influenced by genetic polymorphisms, epigenetic modifications, chronic inflammation, or the presence of competitive ligands, and it directly dictates the magnitude of the biological response to a given circulating hormone concentration. Clinically, understanding this variation is crucial for interpreting hormone lab values and accurately titrating replacement or optimization therapies.