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Receptor Affinity Tuning

Meaning

Receptor Affinity Tuning is a sophisticated pharmacological concept describing the deliberate adjustment of the binding strength, or affinity, between a therapeutic compound and its target receptor on a cell surface or within the cell. This tuning is achieved by designing or selecting compounds, such as selective modulators, that exhibit a precise degree of interaction with the receptor. The clinical objective is to maximize the desired agonistic or antagonistic effect at the target tissue while minimizing non-specific binding and subsequent off-target side effects. It is a core principle in developing highly selective hormonal and peptide mimetics.