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Receptor Affinity Shifts

Meaning

Receptor Affinity Shifts describe a change in the binding strength, or affinity, between a circulating hormone and its specific cellular receptor protein, altering the biological response elicited by a given hormone concentration. A shift toward lower affinity means higher hormone levels are required to achieve the same effect, mimicking a state of resistance. Conversely, increased affinity enhances sensitivity, often seen as a compensatory response to low circulating ligand. These shifts are critical determinants of endocrine system efficiency.