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Receptor Adaptation

Meaning

Receptor Adaptation, also commonly known as desensitization or downregulation, is a fundamental cellular mechanism where the responsiveness of a target cell to a continuous or high concentration of a signaling molecule, such as a hormone, is gradually and physiologically reduced. This crucial process prevents overstimulation and helps the cell maintain internal homeostasis in a fluctuating hormonal environment. Clinically, understanding this mechanism is vital for determining the optimal dosing strategies and long-term efficacy of hormonal therapies.