What is the Origin of Rebound Insomnia?

The term originated in clinical pharmacology to describe the predictable worsening of symptoms observed after stopping short-acting sedative-hypnotic drugs, particularly benzodiazepines and non-benzodiazepine hypnotics, commonly known as Z-drugs. It is a direct consequence of the body's compensatory neurochemical adjustments to the drug's presence.

What is the Mechanism of Rebound Insomnia?

The mechanism involves the central nervous system's compensatory downregulation of its natural sleep-promoting pathways, most notably the GABAergic system, which is typically potentiated by the medication. When the external drug is suddenly removed, the body's native system is temporarily suppressed, leading to a profound, transient state of hyperarousal and intensified sleeplessness until normal neurotransmitter function is restored.

Rebound Insomnia ∞ Area

Rebound Insomnia

Meaning

Rebound Insomnia is a temporary, yet often more severe, exacerbation of sleeplessness that occurs following the abrupt discontinuation of a medication initially prescribed to treat insomnia. This phenomenon is a recognized withdrawal effect and is a critical consideration in the safe and effective management of sleep disorders. It underscores the potential for physiological dependence on certain sleep aids.