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RANKL/OPG Pathway

Meaning

The $text{RANKL/OPG}$ Pathway represents the primary molecular axis regulating the balance between bone resorption and bone formation, a process essential for skeletal health and mineral homeostasis. This axis involves three key molecules: $text{RANKL}$ (Receptor Activator of Nuclear factor kappa-B Ligand), its receptor $text{RANK}$, and the soluble decoy receptor $text{OPG}$ (Osteoprotegerin). The dynamic ratio of $text{RANKL}$ to $text{OPG}$ dictates the overall activity of osteoclasts, the cells that break down bone. Hormonal health, particularly estrogen and androgen status, significantly influences this ratio, underscoring its relevance in conditions like osteoporosis.