Question 1

What is the Meaning of RAD-140?

Accepted Answer

RAD-140, also known as Testolone, is a potent, non-steroidal Selective Androgen Receptor Modulator (SARM) currently under investigation for its potential to treat muscle wasting and certain types of breast cancer. It is recognized for its high anabolic-to-androgenic ratio, suggesting a powerful effect on muscle and bone growth with potentially fewer side effects on non-target tissues. As an unapproved compound, its use outside of clinical trials carries significant health and regulatory risks.

Question 2

What is the Origin of RAD-140?

Accepted Answer

The term is the research code name for the compound developed by Radius Health, reflecting its identity within the pharmaceutical development pipeline. Like other SARMs, its conceptual origin is rooted in the desire to harness the anabolic power of an drogens while avoiding the detrimental systemic effects associated with traditional steroid use. It represents the ongoing effort to create safer, tissue-specific hormonal therapies.

Question 3

What is the Mechanism of RAD-140?

Accepted Answer

RAD-140 exerts its action by binding to the androgen receptor with high affinity, inducing a strong anabolic signal primarily in skeletal muscle and bone cells. This binding promotes muscle hypertrophy and increased bone mineral density. Despite its tissue selectivity, the potent activation of the androgen receptor can still trigger a profound negative feedback on the hypothalamic-pituitary-gonadal axis, leading to a suppression of endogenous testosterone and luteinizing hormone secretion.

RAD-140

Meaning

Origin

Mechanism

How Do Unapproved Androgen Receptor Modulators Affect Liver Function?

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