PYY

Meaning

PYY, or Peptide YY, is a 36-amino acid peptide hormone primarily secreted by the L-cells of the ileum and colon in response to nutrient ingestion, particularly fat. It functions as a potent anorexigenic signal, meaning it promotes a feeling of satiety and reduces appetite, thereby playing a critical role in the short-term regulation of food intake and energy balance. Clinical interest in PYY centers on its therapeutic potential for weight management and metabolic health, as lower levels are often observed in individuals with obesity. It is an integral component of the gut-brain axis communication.

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