Skip to main content

Pulsatile Signal Mimicry

Meaning

Pulsatile Signal Mimicry is a therapeutic dosing technique that involves administering an exogenous signaling molecule, typically a peptide or hormone, in a pattern that closely replicates the natural, rhythmic, and intermittent bursts of secretion characteristic of the body’s own endocrine system. This method is specifically employed to prevent the desensitization or downregulation of target cell receptors, which can occur with continuous, non-physiologic exposure to the signaling molecule. Successful mimicry is critical for maintaining the long-term efficacy of certain hormone and peptide therapies, ensuring that the cellular response remains robust and biologically appropriate.