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Pulsatile Hormone Release

Meaning

Pulsatile hormone release describes the characteristic pattern in which many hormones, particularly those regulating the reproductive and growth axes, are secreted in discrete, rhythmic bursts rather than in a continuous, steady stream. The specific frequency and amplitude of these pulses are highly regulated and carry essential biological information to the target cells. Clinically, maintaining this natural pulsatility is crucial for optimal endocrine function, as continuous administration of certain hormones can paradoxically lead to receptor desensitization and a loss of therapeutic effect.