What is the Origin of Pulmonary Hypertension?

The term combines "pulmonary," referring to the lungs, and "hypertension," denoting abnormally high pressure. Its recognition as a distinct, often life-threatening, vascular disorder led to the specialized clinical classification systems and the subsequent development of targeted vasodilator therapies in the latter half of the 20th century.

What is the Mechanism of Pulmonary Hypertension?

The core mechanism involves pathological remodeling and progressive narrowing of the small pulmonary arterioles, driven by excessive vasoconstriction, proliferation of smooth muscle cells, and in situ thrombosis. This structural and functional change dramatically increases the resistance to blood flow across the pulmonary circulation. While not a primary hormonal disease, certain endocrine imbalances or exogenous hormonal agents can influence the reactivity and remodeling of the pulmonary vasculature, highlighting the systemic regulatory connections.

Pulmonary Hypertension ∞ Area

Pulmonary Hypertension

Meaning

Pulmonary Hypertension (PH) is a severe and progressive cardiopulmonary disorder characterized by an abnormally elevated blood pressure within the pulmonary arteries, the vessels responsible for transporting deoxygenated blood from the right ventricle of the heart to the lungs. This chronic pressure overload forces the right ventricle to work excessively hard, ultimately leading to right-sided heart failure and significant impairment of oxygen exchange and quality of life. PH is a complex vascular pathology that can be primary (idiopathic) or secondary to various underlying cardiac, pulmonary, or systemic diseases.

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HRTioJuly 21, 2025

Pulmonary Hypertension

Meaning

Origin

Mechanism

How Do PDE5 Inhibitors Influence Cardiovascular Health over Time?

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