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PTPN1

Meaning

PTPN1 is the abbreviation for Protein Tyrosine Phosphatase Non-receptor Type 1, a specific enzyme encoded by the PTPN1 gene that functions as a critical negative regulator of key metabolic signaling pathways. PTPN1 acts as a molecular brake on the action of both the insulin and leptin receptors, effectively reducing the cell’s sensitivity to these essential hormones. Elevated activity or overexpression of this enzyme is strongly associated with the clinical manifestation of insulin resistance and metabolic syndrome.