What is the Origin of PT-141 Efficacy Data?

PT-141, or Bremelanotide, is a synthetic peptide analog of alpha-melanocyte-stimulating hormone (α-MSH), and its efficacy data stems from clinical trials initially conducted for sunless tanning, where its unexpected effect on sexual arousal was discovered. The drug’s development and subsequent data generation are rooted in the melanocortin system's role in central sexual function.

What is the Mechanism of PT-141 Efficacy Data?

The efficacy is achieved through PT-141's function as an agonist at the melanocortin receptors (MC3R and MC4R) in the central nervous system, particularly in the hypothalamus and preoptic area. Activation of these receptors initiates neural pathways that directly increase sexual desire and arousal, bypassing the vascular mechanisms targeted by traditional ED medications. The data quantifies the strength of this neurochemical signal.

PT-141 Efficacy Data ∞ Area

PT-141 Efficacy Data

Meaning

PT-141 Efficacy Data refers to the clinical evidence, derived from controlled studies and real-world application, that quantifies the effectiveness of Bremelanotide (PT-141) in treating hypoactive sexual desire disorder (HSDD) in women and erectile dysfunction (ED) in men. This data specifically measures the improvement in sexual desire, arousal, and satisfaction, establishing the peptide’s utility as a central nervous system-acting aphrodisiac.