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PT-141 Clearance

Meaning

PT-141 Clearance refers to the rate and overall process by which the synthetic peptide PT-141 (bremelanotide), a melanocortin receptor agonist used to treat sexual dysfunction, is effectively removed from the systemic circulation through the body’s metabolic and excretory pathways. Clearance is a fundamental pharmacokinetic parameter that directly dictates the compound’s half-life and, consequently, the necessary dosing frequency required to maintain a concentration within the therapeutic window. Efficient clearance, predominantly involving hepatic metabolism and subsequent renal excretion, governs the duration of the compound’s clinical effect.