What is the Origin of Psychosocial Stress Mediators?

This term is derived from the field of psychoneuroendocrinology, which studies the interaction between psychological processes and the endocrine system. The concept of "mediators" highlights the intermediate steps between an external stressor and the internal biological response. It moves beyond a simple stress-response model to account for individual variability in physiological reaction.

What is the Mechanism of Psychosocial Stress Mediators?

The primary mechanism involves the cognitive appraisal of a stressor activating the limbic system, which then signals the hypothalamus to release CRH. CRH acts as a central neurochemical mediator, initiating the HPA axis cascade that culminates in cortisol release. Furthermore, the perceived threat also activates the sympathetic nervous system, releasing catecholamines. These circulating neurohormones then modulate metabolic, immune, and reproductive endocrine function.

Psychosocial Stress Mediators ∞ Area

Psychosocial Stress Mediators

Meaning

The specific psychological, behavioral, and neurochemical factors that translate the perception of social or environmental stressors into tangible physiological and hormonal changes within the body. These mediators include cognitive appraisal, perceived control, coping mechanisms, and the resultant secretion of neurohormones like corticotropin-releasing hormone (CRH) and catecholamines. Understanding these mediators is essential for clinically managing the impact of stress on the endocrine system.