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Psychological Stress

Meaning

Psychological stress is the subjective experience of distress or threat arising from an individual’s appraisal of environmental or internal demands that exceed their perceived coping resources. This cognitive and emotional state triggers a cascade of physiological responses mediated by the central nervous system, profoundly impacting the endocrine system. Sustained psychological stress leads to chronic activation of the hypothalamic-pituitary-adrenal (HPA) axis, resulting in prolonged hypercortisolemia and potential dysregulation of other key hormonal pathways, including thyroid and sex hormones. Managing this stress is paramount for maintaining systemic hormonal balance and resilience.