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Psycho-Neuro-Endocrine Interplay

Meaning

The Psycho-Neuro-Endocrine Interplay describes the complex, bidirectional communication network that continuously links psychological states, the nervous system, and the endocrine system into a single, integrated regulatory unit. Psychological factors, such as stress or emotional state, profoundly influence neural signaling, which in turn modulates the release of hormones like cortisol, thyroid hormones, and sex steroids. Conversely, fluctuations in hormone levels directly affect mood, cognition, and nervous system function, creating a dynamic feedback loop that governs allostatic balance. This holistic understanding is crucial for clinically addressing conditions where psychological stress drives physiological dysfunction and hormonal imbalance.