Question 1

What is the Meaning of Psoriasis?

Accepted Answer

Psoriasis is a chronic, immune-mediated inflammatory skin disorder characterized by the accelerated proliferation of keratinocytes, resulting in thick, erythematous plaques covered with silvery scales. This non-contagious condition is driven by a complex interplay of genetic predisposition, environmental triggers, and systemic immune dysregulation. In the domain of hormonal health, its severity and cyclical flare-ups are often linked to fluctuations in sex hormones and the systemic inflammatory burden associated with metabolic syndrome.

Question 2

What is the Origin of Psoriasis?

Accepted Answer

The term Psoriasis originates from the Greek word "psora," meaning itch or scale, reflecting the primary clinical manifestations of the disease. While recognized for centuries, its modern understanding as a T-cell-mediated autoimmune condition solidified in the late 20th century. Clinical observations have consistently noted its bimodal onset, often peaking around puberty and menopause, suggesting a clear link between the endocrine system and disease activity.

Question 3

What is the Mechanism of Psoriasis?

Accepted Answer

The core mechanism involves the mistaken activation of T-lymphocytes, particularly the Th1 and Th17 subsets, which migrate to the skin and release pro-inflammatory cytokines like TNF-α and interleukins. These cytokines trigger a hyper-proliferative response in the epidermal keratinocytes, drastically shortening the skin cell turnover cycle from weeks to mere days. Hormones, particularly estrogens, can modulate the expression of these inflammatory cytokines, thereby acting as an endogenous factor that either suppresses or exacerbates the inflammatory cascade in the skin.

Psoriasis

Meaning

Origin

Mechanism

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